Arylsulfatase A deficiency causes seminolipid accumulation and a lysosomal storage disorder in Sertoli cells

Sulfogalactosylglycerolipid (SGG) is the major sulfoglycolipid of male germ cells. During spermatogenesis, apoptosis occurs in >50% of total germ cells. Sertoli cells phagocytose these apoptotic germ cells and degrade their components using lysosomal enzymes. Here we demonstrated that SGG was a p...

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Main Authors: Xu, Hongbin, Kongmanas, Kessiri, Kadunganattil, Suraj, Smith, Charles E., Rupar, Tony, Goto-Inoue, Naoko, Hermo, Louis, Faull, Kym F., Tanphaichitr, Nongnuj
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Biochemistry and Molecular Biology 2011
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3220287/
https://ncbi.nlm.nih.gov/pubmed/21965315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M019661
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