Refinement of primate copy number variation hotspots identifies candidate genomic regions evolving under positive selection

BACKGROUND: Copy number variants (CNVs), defined as losses and gains of segments of genomic DNA, are a major source of genomic variation. RESULTS: In this study, we identified over 2,000 human CNVs that overlap with orthologous chimpanzee or orthologous macaque CNVs. Of these, 170 CNVs overlap with...

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Main Authors: Gokcumen, Omer, Babb, Paul L, Iskow, Rebecca C, Zhu, Qihui, Shi, Xinghua, Mills, Ryan E, Ionita-Laza, Iuliana, Vallender, Eric J, Clark, Andrew G, Johnson, Welkin E, Lee, Charles
Formáid: Artigo
Teanga:Inglês
Foilsithe: BioMed Central 2011
Ábhair:
Research
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219974/
https://ncbi.nlm.nih.gov/pubmed/21627829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/gb-2011-12-5-r52
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