Impaired Expression of the Inducible cAMP Early Repressor Accounts for Sustained Adipose CREB Activity in Obesity

OBJECTIVE: Increase in adipose cAMP-responsive element\x{2013}binding protein (CREB) activity promotes adipocyte dysfunction and systemic insulin resistance in obese mice. This is achieved by increasing the expression of activating transcription factor 3 (ATF3). In this study, we investigated whethe...

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Hauptverfasser: Favre, Dimitri, Le Gouill, Eric, Fahmi, Denis, Verdumo, Chantal, Chinetti-Gbaguidi, Giulia, Staels, Bart, Caiazzo, Robert, Pattou, François, Lê, Kim-Anne, Tappy, Luc, Regazzi, Romano, Giusti, Vittorio, Vollenweider, Peter, Waeber, Gérard, Abderrahmani, Amar
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2011
Schlagworte:
Obesity Studies
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219947/
https://ncbi.nlm.nih.gov/pubmed/21998402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1743
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