Wld(S) Enhances Insulin Transcription and Secretion via a SIRT1-Dependent Pathway and Improves Glucose Homeostasis

OBJECTIVE: Wld(S) (Wallerian degeneration slow), a fusion protein from a spontaneous mutation containing full-length nicotinamide mononucleotide adenylyltransferase 1, has NAD biosynthesis activity and protects axon from degeneration robustly. NAD biosynthesis is also implicated in insulin secretion...

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Main Authors: Wu, Jingxia, Zhang, Fang, Yan, Menghong, Wu, Dongmei, Yu, Qiujing, Zhang, Yi, Zhou, Ben, McBurney, Michael W., Zhai, Qiwei
Formato: Artigo
Idioma:Inglês
Publicado: American Diabetes Association 2011
Assuntos:
Islet Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219932/
https://ncbi.nlm.nih.gov/pubmed/21998399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0232
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