Inhibition of IL-10 Production by Maternal Antibodies against Group B Streptococcus GAPDH Confers Immunity to Offspring by Favoring Neutrophil Recruitment

Group B Streptococcus (GBS) is the leading cause of neonatal pneumonia, septicemia, and meningitis. We have previously shown that in adult mice GBS glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is an extracellular virulence factor that induces production of the immunosuppressive...

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Autori principali: Madureira, Pedro, Andrade, Elva Bonifácio, Gama, Bernardo, Oliveira, Liliana, Moreira, Susana, Ribeiro, Adília, Correia-Neves, Margarida, Trieu-Cuot, Patrick, Vilanova, Manuel, Ferreira, Paula
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219712/
https://ncbi.nlm.nih.gov/pubmed/22114550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002363
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