Conformational dynamics of helix 8 in the GPCR rhodopsin controls arrestin activation in the desensitization process

Arrestins are regulatory molecules for G-protein coupled receptor function. In visual rhodopsin, selective binding of arrestin to the cytoplasmic side of light-activated, phosphorylated rhodopsin (P-Rh*) terminates signaling via the G-protein transducin. While the “phosphate-sensor” of arrestin for...

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Bibliografische gegevens
Hoofdauteurs: Kirchberg, Kristina, Kim, Tai-Yang, Möller, Martina, Skegro, Darko, Dasara Raju, Gayathri, Granzin, Joachim, Büldt, Georg, Schlesinger, Ramona, Alexiev, Ulrike
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2011
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219140/
https://ncbi.nlm.nih.gov/pubmed/22039220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1015461108
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