Characterization of dsRNA-induced pancreatitis model reveals the regulatory role of IFN regulatory factor 2 (Irf2) in trypsinogen5 gene transcription

Mice deficient for interferon regulatory factor (Irf)2 (Irf2(−/−) mice) exhibit immunological abnormalities and cannot survive lymphocytic choriomeningitis virus infection. The pancreas of these animals is highly inflamed, a phenotype replicated by treatment with poly(I:C), a synthetic double-strand...

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Dettagli Bibliografici
Autori principali: Hayashi, Hideki, Kohno, Tomoko, Yasui, Kiyoshi, Murota, Hiroyuki, Kimura, Tohru, Duncan, Gordon S., Nakashima, Tomoki, Yamamoto, Kazuo, Katayama, Ichiro, Ma, Yuhua, Chua, Koon Jiew, Suematsu, Takashi, Shimokawa, Isao, Akira, Shizuo, Kubo, Yoshinao, Mak, Tak Wah, Matsuyama, Toshifumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3219097/
https://ncbi.nlm.nih.gov/pubmed/22042864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116273108
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