Potent anti-inflammatory and antinociceptive activity of the endothelin receptor antagonist bosentan in monoarthritic mice

INTRODUCTION: Endothelins are involved in tissue inflammation, pain, edema and cell migration. Our genome-wide microarray analysis revealed that endothelin-1 (ET-1) and endothelin-2 (ET-2) showed a marked up-regulation in dorsal root ganglia during the acute phase of arthritis. We therefore examined...

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Autors principals: Imhof, Anne-Katja, Glück, Laura, Gajda, Mieczyslaw, Bräuer, Rolf, Schaible, Hans-Georg, Schulz, Stefan
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218912/
https://ncbi.nlm.nih.gov/pubmed/21689431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3372
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