Hyaluronan modulates accumulation of hypoxia-inducible factor-1 alpha, inducible nitric oxide synthase, and matrix metalloproteinase-3 in the synovium of rat adjuvant-induced arthritis model

INTRODUCTION: Hypoxia is a feature of the inflamed synovium in rheumatoid arthritis (RA). Intra-articular injection of hyaluronan (HA) may be considered a potential way to treat RA. However, the exact molecular mechanism of HA on decreased cellular responses to hypoxic environment is unclear. The pr...

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Hlavní autoři: Chou, Li-Wei, Wang, John, Chang, Pei-Lin, Hsieh, Yueh-Ling
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218905/
https://ncbi.nlm.nih.gov/pubmed/21679445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3365
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