Systemic sclerosis-associated pulmonary hypertension: why disease-specific composite endpoints are needed

Pulmonary arterial hypertension (PAH) is a serious complication of systemic sclerosis (SSc). In clinical trials PAH-SSc has been grouped with other forms, including idiopathic PAH. The primary endpoint for most pivotal studies was improvement in exercise capacity. However, composite clinical endpoin...

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Detalhes bibliográficos
Main Authors: Denton, Christopher P, Avouac, Jerome, Behrens, Frank, Furst, Daniel E, Foeldvari, Ivan, Humbert, Marc, Huscher, Doerte, Kowal-Bielecka, Otylia, Matucci-Cerinic, Marco, Nash, Peter, Opitz, Christian F, Pittrow, David, Rubin, Lewis J, Seibold, James R, Distler, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Commentary
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218892/
https://ncbi.nlm.nih.gov/pubmed/21699746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3346
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