Notochordal conditioned media from tissue increases proteoglycan accumulation and promotes a healthy nucleus pulposus phenotype in human mesenchymal stem cells

INTRODUCTION: Notochordal cells (NCs) are influential in development of the intervertebral disc (IVD) and species that retain NCs do not degenerate. IVD repair using bone marrow derived mesenchymal stem cells (MSCs) is an attractive approach and the harsh microenvironment of the IVD suggests pre-dif...

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Main Authors: Purmessur, Devina, Schek, Rachel M, Abbott, Rosalyn D, Ballif, Bryan A, Godburn, Karolyn E, Iatridis, James C
格式: Artigo
語言:Inglês
出版: BioMed Central 2011
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218891/
https://ncbi.nlm.nih.gov/pubmed/21627827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar3344
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