Inhibition of herpes simplex thymidine kinase gene expression by DNA methylation is an indirect effect.
The biological activity of in vitro methylated HSV-TK DNA was analysed after microinjection into thymidine kinase negative rat 2 cells. It was found that the fully methylated DNA (Hpa II methylase) was as active as the non methylated control DNA for about 48 hours after injection. DNA reextraction e...
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| Publicado en: | Nucleic Acids Res |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
1985
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| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321886/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2994001/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/13.15.5503 |
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