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Inhibition of herpes simplex thymidine kinase gene expression by DNA methylation is an indirect effect.
The biological activity of in vitro methylated HSV-TK DNA was analysed after microinjection into thymidine kinase negative rat 2 cells. It was found that the fully methylated DNA (Hpa II methylase) was as active as the non methylated control DNA for about 48 hours after injection. DNA reextraction e...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
1985
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| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC321886/ https://ncbi.nlm.nih.gov/pubmed/2994001 |
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