Deletion of PPAR-γ in immune cells enhances susceptibility to antiglomerular basement membrane disease

Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPAR-γ) has been shown to be immunoregulatory in autoimmune diseases by inhibiting production of a number of inflammatory mediators. We investigated whether PPAR-γ gene deletion in hematopoietic cells would...

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Detalhes bibliográficos
Main Authors: Chafin, Cristen, Muse, Sarah, Hontecillas, Raquel, Bassaganya-Riera, Josep, Caudell, David L, Shimp, Samuel K, Rylander, M Nichole, Zhang, John, Li, Liwu, Reilly, Christopher M
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2010
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218741/
https://ncbi.nlm.nih.gov/pubmed/22096362
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JIR.S13394
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