Synergistic induction of CX3CL1 by TNF alpha and IFN gamma in osteoblasts from rheumatoid arthritis: involvement of NF-kappa B and STAT-1 signaling pathways

To explore the regulation of CX3CL1 in inflammatory bone diseases, CX3CL1 expression by osteoblasts (OB) was examined. Human OB isolated from rheumatoid arthritis (RA) patients, osteoarthritis patients, and normal individuals were incubated in the presence of cytokines. Soluble CX3CL1 levels were de...

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Autori principali: Isozaki, Takeo, Kasama, Tsuyoshi, Takahashi, Ryo, Odai, Tsuyoshi, Wakabayashi, Kuninobu, Kanemitsu, Hirohito, Nohtomi, Kyoko, Takeuchi, Hiroko T, Matsukura, Satoshi, Tezuka, Masakazu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove Medical Press 2008
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218717/
https://ncbi.nlm.nih.gov/pubmed/22096344
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