Chelation of Lysosomal Iron Protects Dopaminergic SH-SY5Y Neuroblastoma Cells from Hydrogen Peroxide Toxicity by Precluding Autophagy and Akt Dephosphorylation

In human neuroblastoma SH-SY5Y cells, hydrogen peroxide (H(2)O(2), 200μM) rapidly (< 5 min) induced autophagy, as shown by processing and vacuolar relocation of light chain 3(LC3). Accumulation of autophagosome peaked at 30 min of H(2)O(2) exposure. The continuous presence of H(2)O(2) eventually...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Castino, Roberta, Fiorentino, Ilaria, Cagnin, Monica, Giovia, Antonino, Isidoro, Ciro
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
Assuntos:
Molecular Toxicology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218672/
https://ncbi.nlm.nih.gov/pubmed/21742779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfr179
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares