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Differential Effects of HIF-1 Inhibition by YC-1 on the Overall Outcome and Blood-Brain Barrier Damage in a Rat Model of Ischemic Stroke

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of cellular adaptation to hypoxia and has been suggested as a potent therapeutic target in cerebral ischemia. Here we show in an ischemic stroke model of rats that inhibiting HIF-1 and its downstream genes by 3-(5'-hydroxymethyl-2'-f...

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Bibliografiske detaljer
Main Authors: Yan, Jingqi, Zhou, Bo, Taheri, Saeid, Shi, Honglian
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3218033/
https://ncbi.nlm.nih.gov/pubmed/22110762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027798
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