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Not all transmembrane helices are born equal: Towards the extension of the sequence homology concept to membrane proteins

BACKGROUND: Sequence homology considerations widely used to transfer functional annotation to uncharacterized protein sequences require special precautions in the case of non-globular sequence segments including membrane-spanning stretches composed of non-polar residues. Simple, quantitative criteri...

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Detalhes bibliográficos
Main Authors: Wong, Wing-Cheong, Maurer-Stroh, Sebastian, Eisenhaber, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217874/
https://ncbi.nlm.nih.gov/pubmed/22024092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1745-6150-6-57
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