Mouse pharmacological models of cognitive disruption relevant to schizophrenia

Schizophrenia is a debilitating cognitive disorder. The link between cognitive debilitation and functional outcome in patients with schizophrenia has prompted research to develop procognitive therapies. It is hoped that by improving cognition in these patients, their functional outcome will also imp...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: YOUNG, Jared W, POWELL, Susan B, GEYER, Mark A
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217063/
https://ncbi.nlm.nih.gov/pubmed/21726569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2011.06.013
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
id pubmed-3217063
record_format dspace
spelling pubmed-32170632013-03-01 Mouse pharmacological models of cognitive disruption relevant to schizophrenia YOUNG, Jared W POWELL, Susan B GEYER, Mark A Neuropharmacology Article Schizophrenia is a debilitating cognitive disorder. The link between cognitive debilitation and functional outcome in patients with schizophrenia has prompted research to develop procognitive therapies. It is hoped that by improving cognition in these patients, their functional outcome will also improve. Although no established treatments exist as yet, progress has been made toward understanding how to evaluate putative compounds in the clinic. Genetic mouse models and pharmacological rat models of cognitive disruption are being developed that may help to evaluate these putative compounds preclinically. Considering the increased number of genetic mouse models relevant to schizophrenia, there is a need to evaluate pharmacological manipulations on cognition in mice. Here we review the current literature on mouse pharmacological models relevant to schizophrenia. In this review, we discuss where different pharmacological effects between rats and mice on cognitive tasks are observed and assess the validity offered by these models. We conclude that the predictive validity of these models is currently difficult to assess and that much more needs to be done to develop useful mouse pharmacological models of cognitive disruption in schizophrenia. 2011-06-29 2012-03 /pmc/articles/PMC3217063/ /pubmed/21726569 http://dx.doi.org/10.1016/j.neuropharm.2011.06.013 Text en © 2011 Elsevier Ltd. All rights reserved.
institution US NLM
collection PubMed Central
language Inglês
format Artigo
topic Article
spellingShingle Article
YOUNG, Jared W
POWELL, Susan B
GEYER, Mark A
Mouse pharmacological models of cognitive disruption relevant to schizophrenia
description Schizophrenia is a debilitating cognitive disorder. The link between cognitive debilitation and functional outcome in patients with schizophrenia has prompted research to develop procognitive therapies. It is hoped that by improving cognition in these patients, their functional outcome will also improve. Although no established treatments exist as yet, progress has been made toward understanding how to evaluate putative compounds in the clinic. Genetic mouse models and pharmacological rat models of cognitive disruption are being developed that may help to evaluate these putative compounds preclinically. Considering the increased number of genetic mouse models relevant to schizophrenia, there is a need to evaluate pharmacological manipulations on cognition in mice. Here we review the current literature on mouse pharmacological models relevant to schizophrenia. In this review, we discuss where different pharmacological effects between rats and mice on cognitive tasks are observed and assess the validity offered by these models. We conclude that the predictive validity of these models is currently difficult to assess and that much more needs to be done to develop useful mouse pharmacological models of cognitive disruption in schizophrenia.
author YOUNG, Jared W
POWELL, Susan B
GEYER, Mark A
author_facet YOUNG, Jared W
POWELL, Susan B
GEYER, Mark A
author_sort YOUNG, Jared W
title Mouse pharmacological models of cognitive disruption relevant to schizophrenia
title_short Mouse pharmacological models of cognitive disruption relevant to schizophrenia
title_full Mouse pharmacological models of cognitive disruption relevant to schizophrenia
title_fullStr Mouse pharmacological models of cognitive disruption relevant to schizophrenia
title_full_unstemmed Mouse pharmacological models of cognitive disruption relevant to schizophrenia
title_sort mouse pharmacological models of cognitive disruption relevant to schizophrenia
publishDate 2011
url https://ncbi.nlm.nih.gov/pmc/articles/PMC3217063/
https://ncbi.nlm.nih.gov/pubmed/21726569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2011.06.013
_version_ 1756111051837931520