Decreased MCM2-6 in Drosophila S2 Cells Does Not Generate Significant DNA Damage or Cause a Marked Increase in Sensitivity to Replication Interference

A reduction in the level of some MCM proteins in human cancer cells (MCM5 in U20S cells or MCM3 in Hela cells) causes a rapid increase in the level of DNA damage under normal conditions of cell proliferation and a loss of viability when the cells are subjected to replication interference. Here we sh...

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Autors principals: Crevel, Isabelle, Crevel, Gilles, Gostan, Thierry, de Renty, Christelle, Coulon, Vincent, Cotterill, Sue
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3216938/
https://ncbi.nlm.nih.gov/pubmed/22102875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027101
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