Influence of Polymorphisms in the RANKL/RANK/OPG Signaling Pathway on Volumetric Bone Mineral Density and Bone Geometry at the Forearm in Men

We sought to determine the influence of single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG on volumetric bone mineral density (vBMD) and bone geometry at the radius in men. Pairwise tag SNPs (r (2) ≥ 0.8) for RANKL (n = 8), RANK (n = 44), and OPG (n = 22) and five SNPs near RANKL and OPG...

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Bibliographic Details
Main Authors: Roshandel, Delnaz, Holliday, Kate L., Pye, Stephen R., Ward, Kate A., Boonen, Steven, Vanderschueren, Dirk, Borghs, Herman, Huhtaniemi, Ilpo T., Adams, Judith E., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Lean, Michael E., Pendleton, Neil, Punab, Margus, Silman, Alan J., Wu, Frederick C., Thomson, Wendy, O’Neill, Terence W.
Format: Artigo
Language:Inglês
Published: Springer-Verlag 2011
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215872/
https://ncbi.nlm.nih.gov/pubmed/21964949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-011-9532-y
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