Influence of Polymorphisms in the RANKL/RANK/OPG Signaling Pathway on Volumetric Bone Mineral Density and Bone Geometry at the Forearm in Men

We sought to determine the influence of single-nucleotide polymorphisms (SNPs) in RANKL, RANK, and OPG on volumetric bone mineral density (vBMD) and bone geometry at the radius in men. Pairwise tag SNPs (r (2) ≥ 0.8) for RANKL (n = 8), RANK (n = 44), and OPG (n = 22) and five SNPs near RANKL and OPG...

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Main Authors: Roshandel, Delnaz, Holliday, Kate L., Pye, Stephen R., Ward, Kate A., Boonen, Steven, Vanderschueren, Dirk, Borghs, Herman, Huhtaniemi, Ilpo T., Adams, Judith E., Bartfai, Gyorgy, Casanueva, Felipe F., Finn, Joseph D., Forti, Gianni, Giwercman, Aleksander, Han, Thang S., Kula, Krzysztof, Lean, Michael E., Pendleton, Neil, Punab, Margus, Silman, Alan J., Wu, Frederick C., Thomson, Wendy, O’Neill, Terence W.
Format: Artigo
Jezik:Inglês
Izdano: Springer-Verlag 2011
Teme:
Original Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215872/
https://ncbi.nlm.nih.gov/pubmed/21964949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-011-9532-y
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