Preclinical evaluation of the antitumor activity of bortezomib in combination with vitamin C or with epigallocatechin gallate, a component of green tea

PURPOSE: To investigate whether clinically relevant levels of epigallocatechin gallate (EGCG, a component of green tea) or vitamin C (ascorbic acid) could antagonize bortezomib antitumor activity in CWR22 human prostate xenograft tumors. METHODS: The pharmacokinetics (PK) of EGCG and ascorbic acid w...

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Autors principals: Bannerman, Bret, Xu, Ling, Jones, Matthew, Tsu, Christopher, Yu, Jie, Hales, Paul, Monbaliu, Johan, Fleming, Paul, Dick, Lawrence, Manfredi, Mark, Claiborne, Christopher, Bolen, Joseph, Kupperman, Erik, Berger, Allison
Format: Artigo
Idioma:Inglês
Publicat: Springer-Verlag 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215871/
https://ncbi.nlm.nih.gov/pubmed/21400028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-011-1591-2
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