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Suppression of Neurotoxic Lesion-Induced Seizure Activity: Evidence for a Permanent Role for the Hippocampus in Contextual Memory

Damage to the hippocampus (HPC) using the excitotoxin N-methyl-D-aspartate (NMDA) can cause retrograde amnesia for contextual fear memory. This amnesia is typically attributed to loss of cells in the HPC. However, NMDA is also known to cause intense neuronal discharge (seizure activity) during the h...

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Autori principali: Sparks, Fraser T., Lehmann, Hugo, Hernandez, Khadaryna, Sutherland, Robert J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215748/
https://ncbi.nlm.nih.gov/pubmed/22110648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027426
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