Decrease of virulence for BALB/c mice produced by continuous subculturing of Nocardia brasiliensis

BACKGROUND: Subculturing has been extensively used to attenuate human pathogens. In this work we studied the effect of continuous subculturing of Nocardia brasiliensis HUJEG-1 on virulence in a murine model. METHODS: Nocardia brasiliensis HUJEG-1 was subcultured up to 130 times on brain heart infusi...

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Autores principales: Almaguer-Chávez, Janeth A, Welsh, Oliverio, Lozano-Garza, Hector G, Said-Fernández, Salvador, Romero-Díaz, Víktor J, Ocampo-Candiani, Jorge, Vera-Cabrera, Lucio
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2011
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215677/
https://ncbi.nlm.nih.gov/pubmed/22029431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2334-11-290
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