Depletion of β-catenin from mature hepatocytes of mice promotes expansion of hepatic progenitor cells and tumor development

Depletion of β-catenin impairs regeneration of the rapid turn-over gut epithelial cells, but appears dispensable for that of the slow turn-over mature hepatocytes in mice until 1 y of age. As the life span of mature murine hepatocytes is about 400 d, we studied conditional β-catenin knockout mice (A...

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Detalhes bibliográficos
Main Authors: Wang, Er-Yea, Yeh, Shiou-Hwei, Tsai, Ting-Fen, Huang, Hsiang-Po, Jeng, Yung-Ming, Lin, Wei-Hsiang, Chen, Wei-Chih, Yeh, Kun-Huei, Chen, Pei-Jer, Chen, Ding-Shinn
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3215019/
https://ncbi.nlm.nih.gov/pubmed/22042854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1116386108
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