The NeuC Protein of Escherichia coli K1 Is a UDP N-Acetylglucosamine 2-Epimerase

The K1 capsule is an essential virulence determinant of Escherichia coli strains that cause meningitis in neonates. Biosynthesis and transport of the capsule, an α-2,8-linked polymer of sialic acid, are encoded by the 17-kb kps gene cluster. We deleted neuC, a K1 gene implicated in sialic acid synth...

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Bibliografiske detaljer
Main Authors: Vann, Willie F., Daines, Dayle A., Murkin, Andrew S., Tanner, Martin E., Chaffin, Donald O., Rubens, Craig E., Vionnet, Justine, Silver, Richard P.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Enzymes and Proteins
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC321479/
https://ncbi.nlm.nih.gov/pubmed/14729696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.186.3.706-712.2004
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