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E2a/Pbx1 Induces the Rapid Proliferation of Stem Cell Factor-Dependent Murine Pro-T Cells That Cause Acute T-Lymphoid or Myeloid Leukemias in Mice

Oncoprotein E2a/Pbx1 is produced by the t(1;19) chromosomal translocation of human pre-B acute lymphoblastic leukemia. E2a/Pbx1 blocks differentiation of primary myeloid progenitors but, paradoxically, induces apoptosis in established pre-B-cell lines, and no transforming function of E2a/Pbx1 has be...

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Sonraí Bibleagrafaíochta
Main Authors: Sykes, David B., Kamps, Mark P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2004
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC321418/
https://ncbi.nlm.nih.gov/pubmed/14729970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.3.1256-1269.2004
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