Abundant Pleiotropy in Human Complex Diseases and Traits

We present a systematic review of pleiotropy among SNPs and genes reported to show genome-wide association with common complex diseases and traits. We find abundant evidence of pleiotropy; 233 (16.9%) genes and 77 (4.6%) SNPs show pleiotropic effects. SNP pleiotropic status was associated with gene...

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Hauptverfasser: Sivakumaran, Shanya, Agakov, Felix, Theodoratou, Evropi, Prendergast, James G., Zgaga, Lina, Manolio, Teri, Rudan, Igor, McKeigue, Paul, Wilson, James F., Campbell, Harry
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213397/
https://ncbi.nlm.nih.gov/pubmed/22077970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.10.004
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