Mutation Altering the miR-184 Seed Region Causes Familial Keratoconus with Cataract

MicroRNAs (miRNAs) bind to complementary sequences within the 3′ untranslated region (UTR) of mRNAs from hundreds of target genes, leading either to mRNA degradation or suppression of translation. We found that a mutation in the seed region of miR-184 (MIR184) is responsible for familial severe kera...

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Detalhes bibliográficos
Main Authors: Hughes, Anne E., Bradley, Declan T., Campbell, Malcolm, Lechner, Judith, Dash, Durga P., Simpson, David A., Willoughby, Colin E.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213395/
https://ncbi.nlm.nih.gov/pubmed/21996275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajhg.2011.09.014
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