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A Density-Dependent Switch Drives Stochastic Clustering and Polarization of Signaling Molecules

Positive feedback plays a key role in the ability of signaling molecules to form highly localized clusters in the membrane or cytosol of cells. Such clustering can occur in the absence of localizing mechanisms such as pre-existing spatial cues, diffusional barriers, or molecular cross-linking. What...

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Autors principals: Jilkine, Alexandra, Angenent, Sigurd B., Wu, Lani F., Altschuler, Steven J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3213192/
https://ncbi.nlm.nih.gov/pubmed/22102805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002271
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