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Adaptive increase of O6-methylguanine-acceptor protein in HeLa cells following N-methyl-N'-nitro-N-nitrosoguanidine treatment.

We have assayed in extracts of HeLa cells the amount of acceptor protein that removes O6-methylguanine adducts from alkylated DNA. Cells were treated with single or multiple nontoxic doses of N-methyl-N'-nitrosoguanidine (MNNG) and the extracts were analyzed up to 32 h after the last exposure. The a...

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Udgivet i:Nucleic Acids Res
Principais autores: Waldstein, E A, Cao, E H, Setlow, R B
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 1982
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC321114/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7133992/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/10.15.4595
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