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Role of Solvation Effects in Protein Denaturation: From Thermodynamics to Single Molecules and Back
Protein stability often is studied in vitro through the use of urea and guanidinium chloride, chemical cosolvents that disrupt protein native structure. Much controversy still surrounds the underlying mechanism by which these molecules denature proteins. Here we review current thinking on various as...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3211090/ https://ncbi.nlm.nih.gov/pubmed/21219136 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-physchem-032210-103531 |
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