Tumor engraftment in nude mice and enrichment in stroma-related gene pathways predicts poor survival and resistance to gemcitabine in patients with pancreatic cancer

PURPOSE: To evaluate prospectively the engraftment rate, factors influencing engraftment, and predictability of clinical outcome of low-passage xenografts from patients with resectable pancreatic ductal adenocarcinoma (PDA) and to establish a bank of PDA xenografts. EXPERIMENTAL DESIGN: Patients wit...

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Main Authors: Garrido-Laguna, Ignacio, Uson, Maria, Rajeshkumar, N.V., Tan, Aik Choon, de Oliveira, Elizabeth, Karikari, Collins, Villaroel, Maria C., Salomon, Ana, Taylor, Gretchen, Sharma, Rajni, Hruban, Ralph H., Maitra, Anirban, Laheru, Daniel, Rubio-Viqueira, Belén, Jimeno, Antonio, Hidalgo, Manuel
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210576/
https://ncbi.nlm.nih.gov/pubmed/21742805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0341
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