SUMO2/3 conjugation is an endogenous neuroprotective mechanism

Small ubiquitin-like modifier (SUMO)2/3 but not SUMO1 conjugation is activated after transient cerebral ischemia. To investigate its function, we blocked neuronal SUMO2/3 translation through lentiviral microRNA delivery in primary cortical neurons. Viability was unaffected by SUMO2/3 silencing unles...

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Detalhes bibliográficos
Main Authors: Datwyler, Anna Lena, Lättig-Tünnemann, Gisela, Yang, Wei, Paschen, Wulf, Lee, Sabrina Lin Lin, Dirnagl, Ulrich, Endres, Matthias, Harms, Christoph
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Brief Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210338/
https://ncbi.nlm.nih.gov/pubmed/21863037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2011.112
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