Dissociation of Bone Resorption and Bone Formation in Adult Mice with a Non-Functional V-ATPase in Osteoclasts Leads to Increased Bone Strength

Osteopetrosis caused by defective acid secretion by the osteoclast, is characterized by defective bone resorption, increased osteoclast numbers, while bone formation is normal or increased. In contrast the bones are of poor quality, despite this uncoupling of formation from resorption. To shed light...

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Detalhes bibliográficos
Main Authors: Henriksen, Kim, Flores, Carmen, Thomsen, Jesper S., Brüel, Anne-Marie, Thudium, Christian S., Neutzsky-Wulff, Anita V., Langenbach, Geerling E. J., Sims, Natalie, Askmyr, Maria, Martin, Thomas J., Everts, Vincent, Karsdal, Morten A., Richter, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210177/
https://ncbi.nlm.nih.gov/pubmed/22087326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027482
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