The PNPLA3 rs738409 148M/M Genotype Is a Risk Factor for Liver Cancer in Alcoholic Cirrhosis but Shows No or Weak Association in Hepatitis C Cirrhosis

BACKGROUND: An isoleucine>methionine mutation at position 148 in the PNPLA3 gene (p.I148M, rs738409) has recently been identified as a susceptibility factor for liver damage in steatohepatitis. Here, we studied whether the PNPLA3 rs738409 polymorphism also affects predisposition to hepatocellular...

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Hlavní autoři: Nischalke, Hans Dieter, Berger, Cordula, Luda, Carolin, Berg, Thomas, Müller, Tobias, Grünhage, Frank, Lammert, Frank, Coenen, Martin, Krämer, Benjamin, Körner, Christian, Vidovic, Natascha, Oldenburg, Johannes, Nattermann, Jacob, Sauerbruch, Tilman, Spengler, Ulrich
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210131/
https://ncbi.nlm.nih.gov/pubmed/22087248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027087
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