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Targeting Specific Regions of the Notch3 Ligand-Binding Domain Induces Apoptosis And Inhibits Tumor Growth In Lung Cancer
Like many signaling pathways in development, the Notch pathway also plays a role in cancers when it is dysregulated. Studies involving deletions of several epidermal growth factor (EGF)-like repeats in the extracellular domains of Drosophila Notch and mammalian Notch1 have identified potential ligan...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3210016/ https://ncbi.nlm.nih.gov/pubmed/20068176 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3293 |
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