Using Tandem Mass Spectrometry in Targeted Mode to Identify Activators of Class IA PI3K in Cancer

PI3K is activated in some cancers by direct mutation, but it is activated more commonly in cancer by mutation of upstream acting receptor tyrosine kinases (TKs). At present, there is no systematic method to determine which TK signaling cascades activate PI3K in certain cancers, despite the likely ut...

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Autori principali: Yang, Xuemei, Turke, Alexa B., Qi, Jie, Song, Youngchul, Rexer, Brent N., Miller, Todd W., Jänne, Pasi A., Arteaga, Carlos L., Cantley, Lewis C., Engelman, Jeffrey A., Asara, John M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209668/
https://ncbi.nlm.nih.gov/pubmed/21775521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0445
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