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Epstein-Barr Virus BamHI W Repeat Number Limits EBNA2/EBNA-LP Coexpression in Newly Infected B Cells and the Efficiency of B-Cell Transformation: a Rationale for the Multiple W Repeats in Wild-Type Virus Strains

The genome of Epstein-Barr virus (EBV), a gammaherpesvirus with potent B-cell growth-transforming ability, contains multiple copies of a 3-kb BamHI W repeat sequence; each repeat carries (i) a promoter (Wp) that initiates transformation by driving EBNA-LP and EBNA2 expression and (ii) the W1W2 exons...

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書誌詳細
主要な著者: Tierney, Rosemary J., Kao, Kuan-Yu, Nagra, Jasdeep K., Rickinson, Alan B.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209410/
https://ncbi.nlm.nih.gov/pubmed/21957300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06059-11
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