Modulation of NKG2D-Mediated Cytotoxic Functions of Natural Killer Cells by Viral Protein R from HIV-1 Primary Isolates

HIV-1 viral protein R (Vpr) from laboratory-adapted virus strains activates the DNA damage/stress sensor ATR kinase and induces cell cycle arrest at the G(2)/M phase through a process that requires Vpr to engage the DDB1-CUL4A (VprBP/DCAF-1) E3 ligase complex. Activation of this DNA damage/stress ch...

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Main Authors: Pham, Tram N. Q., Richard, Jonathan, Gerard, Francine C. A., Power, Christopher, Cohen, Éric A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209390/
https://ncbi.nlm.nih.gov/pubmed/21957298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05835-11
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