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Loss of type I procollagen gene expression in SV40-transformed human fibroblasts is accompanied by hypermethylation of these genes.

Transformation of human lung fibroblasts (WI-38) by Simian Virus 40 (SV40) resulted in a decline of 25-30% in the amount of secreted collagen. The collagen produced by the transformed fibroblasts contained no type I collagen (i.e. alpha 1(I) and alpha 2 chains), which was the major collagen componen...

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Bibliografske podrobnosti
Main Authors: Parker, M I, Judge, K, Gevers, W
Format: Artigo
Jezik:Inglês
Izdano: 1982
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC320937/
https://ncbi.nlm.nih.gov/pubmed/6292857
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