Epigenetic Mechanism Underlying the Development of Polycystic Ovary Syndrome (PCOS)-Like Phenotypes in Prenatally Androgenized Rhesus Monkeys

The pathogenesis of polycystic ovary syndrome (PCOS) is poorly understood. PCOS-like phenotypes are produced by prenatal androgenization (PA) of female rhesus monkeys. We hypothesize that perturbation of the epigenome, through altered DNA methylation, is one of the mechanisms whereby PA reprograms m...

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Detalhes bibliográficos
Main Authors: Xu, Ning, Kwon, Soonil, Abbott, David H., Geller, David H., Dumesic, Daniel A., Azziz, Ricardo, Guo, Xiuqing, Goodarzi, Mark O.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208630/
https://ncbi.nlm.nih.gov/pubmed/22076147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027286
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