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Epigenetic Mechanism Underlying the Development of Polycystic Ovary Syndrome (PCOS)-Like Phenotypes in Prenatally Androgenized Rhesus Monkeys
The pathogenesis of polycystic ovary syndrome (PCOS) is poorly understood. PCOS-like phenotypes are produced by prenatal androgenization (PA) of female rhesus monkeys. We hypothesize that perturbation of the epigenome, through altered DNA methylation, is one of the mechanisms whereby PA reprograms m...
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Autori principali: | , , , , , , , |
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Natura: | Artigo |
Lingua: | Inglês |
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Public Library of Science
2011
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Soggetti: | |
Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3208630/ https://ncbi.nlm.nih.gov/pubmed/22076147 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027286 |
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