Epigenetic Mechanism Underlying the Development of Polycystic Ovary Syndrome (PCOS)-Like Phenotypes in Prenatally Androgenized Rhesus Monkeys

The pathogenesis of polycystic ovary syndrome (PCOS) is poorly understood. PCOS-like phenotypes are produced by prenatal androgenization (PA) of female rhesus monkeys. We hypothesize that perturbation of the epigenome, through altered DNA methylation, is one of the mechanisms whereby PA reprograms m...

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Autors principals: Xu, Ning, Kwon, Soonil, Abbott, David H., Geller, David H., Dumesic, Daniel A., Azziz, Ricardo, Guo, Xiuqing, Goodarzi, Mark O.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208630/
https://ncbi.nlm.nih.gov/pubmed/22076147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027286
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