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Epigenetic Mechanism Underlying the Development of Polycystic Ovary Syndrome (PCOS)-Like Phenotypes in Prenatally Androgenized Rhesus Monkeys

The pathogenesis of polycystic ovary syndrome (PCOS) is poorly understood. PCOS-like phenotypes are produced by prenatal androgenization (PA) of female rhesus monkeys. We hypothesize that perturbation of the epigenome, through altered DNA methylation, is one of the mechanisms whereby PA reprograms m...

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מידע ביבליוגרפי
Main Authors: Xu, Ning, Kwon, Soonil, Abbott, David H., Geller, David H., Dumesic, Daniel A., Azziz, Ricardo, Guo, Xiuqing, Goodarzi, Mark O.
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science 2011
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208630/
https://ncbi.nlm.nih.gov/pubmed/22076147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027286
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