Inhibition of IL-32 activation by α-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model

Interleukin (IL)–32 was originally identified in natural killer cells and IL-2–activated human T lymphocytes. As T cells are activated in allogeneic transplantation, we determined the role of IL-32 in human mixed lymphocyte cultures (MLCs) and GVHD. In allogeneic MLCs, IL-32 increased two-fold in re...

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Detalhes bibliográficos
Main Authors: Marcondes, A. Mario, Li, Xiang, Tabellini, Laura, Bartenstein, Matthias, Kabacka, Julia, Sale, George E., Hansen, John A., Dinarello, Charles A., Deeg, H. Joachim
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208308/
https://ncbi.nlm.nih.gov/pubmed/21900190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-07-365247
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