Inflammasome activation and IL-1β target IL-1α for secretion as opposed to surface expression

Interleukin-1α (IL-1α) and -β both bind to the same IL-1 receptor (IL-1R) and are potent proinflammatory cytokines. Production of proinflammatory (pro)–IL-1α and pro–IL-1β is induced by Toll-like receptor (TLR)-mediated NF-κB activation. Additional stimulus involving activation of the inflammasome a...

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Detalhes bibliográficos
Main Authors: Fettelschoss, Antonia, Kistowska, Magdalena, LeibundGut-Landmann, Salomé, Beer, Hans-Dietmar, Johansen, Pål, Senti, Gabriela, Contassot, Emmanuel, Bachmann, Martin F., French, Lars E., Oxenius, Annette, Kündig, Thomas M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207698/
https://ncbi.nlm.nih.gov/pubmed/22006336
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1109176108
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