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Noninternalizing monoclonal antibodies are suitable candidates for 125I radioimmunotherapy of small-volume peritoneal carcinomatosis
We have previously shown that, in vitro, monoclonal antibodies (mAbs) labeled with the Auger electron emitter (125)I are more cytotoxic if they remain at the cell surface and do not internalize in the cytoplasm. Here, we assessed in vivo the biological efficiency of internalizing and non internalizi...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Society of Nuclear Medicine
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3206883/ https://ncbi.nlm.nih.gov/pubmed/19910417 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2967/jnumed.109.066993 |
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