A Single Nucleotide in Stem Loop II of 5′-Untranslated Region Contributes to Virulence of Enterovirus 71 in Mice

BACKGROUND: Enterovirus 71 (EV71) has emerged as a neuroinvasive virus responsible for several large outbreaks in the Asia-Pacific region while virulence determinant remains unexplored. PRINCIPAL FINDINGS: In this report, we investigated increased virulence of unadapted EV71 clinical isolate 237 as...

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Main Authors: Yeh, Ming-Te, Wang, Shainn-Wei, Yu, Chun-Keung, Lin, Kuei-Hsiang, Lei, Huan-Yao, Su, Ih-Jen, Wang, Jen-Ren
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206083/
https://ncbi.nlm.nih.gov/pubmed/22069490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027082
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