Alpha 1,3-Galactosyltransferase Deficiency in Pigs Increases Sialyltransferase Activities That Potentially Raise Non-Gal Xenoantigenicity

We examined whether deficiency of the GGTA1 gene in pigs altered the expression of several glycosyltransferase genes. Real-time RT-PCR and glycosyltransferase activity showed that 2 sialyltransferases [α2,3-sialyltransferase (α2,3ST) and α2,6-sialyltransferase (α2,6ST)] in the heterozygote GalT KO l...

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Main Authors: Park, Jong-Yi, Park, Mi-Ryung, Kwon, Deug-Nam, Kang, Min-Hui, Oh, Mihye, Han, Jae-Woong, Cho, Ssang-Goo, Park, Chankyu, Kim, Dong-Ku, Song, Hyuk, Oh, Jae-Wook, Kim, Jin-Hoi
格式: Artigo
語言:Inglês
出版: Hindawi Publishing Corporation 2011
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205825/
https://ncbi.nlm.nih.gov/pubmed/22131812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/560850
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