SET oncoprotein overexpression in B-cell chronic lymphocytic leukemia and non-Hodgkin lymphoma: a predictor of aggressive disease and a new treatment target

B-cell chronic lymphocytic leukemia (CLL), an incurable leukemia, is characterized by defective apoptosis. We found that the SET oncoprotein, a potent inhibitor of the protein phosphatase 2A (PP2A) tumor suppressor, is overexpressed in primary CLL cells and B-cell non-Hodgkin lymphoma (NHL) cell lin...

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Detalhes bibliográficos
Main Authors: Christensen, Dale J., Chen, Youwei, Oddo, Jessica, Matta, Karen M., Neil, Jessica, Davis, Evan D., Volkheimer, Alicia D., Lanasa, Mark C., Friedman, Daphne R., Goodman, Barbara K., Gockerman, Jon P., Diehl, Louis F., de Castro, Carlos M., Moore, Joseph O., Vitek, Michael P., Weinberg, J. Brice
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204732/
https://ncbi.nlm.nih.gov/pubmed/21844565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-351072
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