Fusion with extracellular domain of cytotoxic T-lymphocyte-associated-antigen 4 leads to enhancement of immunogenicity of Hantaan virus DNA vaccines in C57BL/6 mice

BACKGROUND: Hantaan virus (HTNV) is the causative agent of the most severe form of a rodent-borne disease known as hemorrhagic fever with renal syndrome (HFRS). A safe and effective HTNV vaccine is needed. Vaccination with DNA constructs expressing fused antigen with bioactive factors, has shown pro...

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Detalhes bibliográficos
Main Authors: Liu, Feng, Liang, Mifang, Cao, Shouchun, Liu, Qinzhi, Zhang, Quanfu, Li, Chuan, Zhang, Shuo, Wang, Shiwen, Li, Dexin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2011
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204296/
https://ncbi.nlm.nih.gov/pubmed/21943202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1743-422X-8-448
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