IL-27 Inhibits Hyperglycemia and Pancreatic Islet Inflammation Induced by Streptozotocin in Mice

Inflammation driven by immune cells and pro-inflammatory cytokines is implicated in pancreatic β-cell injury, leading to the development of diabetes mellitus. IL-27, a cytokine consisting of IL-27p28 and Epstein-Barr virus–induced gene 3 (EBI3), binds a membrane-bound heterodimeric receptor consisti...

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Main Authors: Fujimoto, Hirokazu, Hirase, Tetsuaki, Miyazaki, Yoshiyuki, Hara, Hiromitsu, Ide-Iwata, Noriko, Nishimoto-Hazuku, Ai, Saris, Christiaan J.M., Yoshida, Hiroki, Node, Koichi
Format: Artigo
Jezik:Inglês
Izdano: American Society for Investigative Pathology 2011
Teme:
Regular Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204191/
https://ncbi.nlm.nih.gov/pubmed/21925473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.08.001
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